RICHMOND, Va. - Most of the time, the apes are simply not needed. That's a new finding from the Institute of Medicine about whether chimpanzees are necessary for biomedical and behavioral research funded by the National Institutes of Health.

Dr. Jeffrey Kahn at Johns Hopkins Berman Institute of Bioethics in Baltimore, who helped prepare the report, says advances in other technologies can replace the animals for most projects.

"Humanized animals, in vitro is another approach, and there's even some work to try to create computer-based models that may obviate the need for chimpanzees."

The term humanized animals generally refers to animals which have had human genes inserted to make them suitable for testing of medical products meant for humans.

Dr. Kahn says the committee did not reach agreement on whether chimpanzees are essential to research in developing a Hepatitis C vaccine. Chimpanzees and humans are the only two species susceptible to the disease, and chimpanzees' immune systems are better at clearing it.

"It's a disease that affects many millions of people worldwide, and the majority reason for liver transplant in the United States. So, it's an important disease."

The report sets stringent guidelines for situations in which chimpanzees are essential, along with requirements for techniques that are minimally invasive and allow for animals to be in natural habitats, when possible.

A bill that would ban lab testing on chimpanzees has been introduced in Congress, and Virginia's 8th District Congressman Jim Moran is one of more than a hundred co-sponsors. This new study was ordered by Congress to assess the need to use chimpanzees in research.

See the report at ht.ly/80QVr.




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Some Hoosiers want Indiana lawmakers to rethink proposed legislation that would usurp existing local laws that prohibit retailers from selling puppies. Legislators listened to emotional testimony during a 3.5 hour hearing on the proposed law, which was revived from last year's session.

Dr. Scott Robinson, a physician and attorney who also founded a low-cost spay and neuter center in Indianapolis, told the Senate Agriculture Committee there's no mystery about House Bill 1412. Pet stores support the legislation because they're trying to keep themselves from being forced out of business.

"I've been involved in animal welfare for a long time, and I've seen over the years many wolves in sheep's clothing and that's what this is about," Robinson argued. "There's plenty of regulations that can be made to monitor puppy mills, but this is designed to usurp local control of communities and protect pet stores."

Robinson said the issue is not a Republican or Democrat problem -- regardless of party affiliation, people care about their animals. If passed, the bill will overturn bans on retail puppy sales in 21 Indiana communities. Proponents say the law would allow pet stores the option to sell puppies as long as the animals are from ethically sourced suppliers.

Lori Wilson, CEO of Uncle Bill's Pet Centers, who operates six stores throughout Indiana, supports the proposed legislation.

"We are very transparent. We're open door," she intoned. "Being USDA, you have to be open door, so we are very picky. I actually go to many of the kennels to make sure that they are exactly what we want them to be and need them to be, to be able to source humanely and ethically raised puppies."

Opponents say the bill lacks funding to support the agencies tasked with enforcing laws. This is not a budget year for Indiana lawmakers, so any funding to support the proposed mandate would not come before 2025.


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Researchers at Colorado State University are making headway in identifying how osteoarthritis progresses in horses, and their findings could one day also help people who develop the degenerative disease after injuring a knee, elbow or shoulder.

Lynn Pezzanite, doctor of veterinary medicine and assistant professor at Colorado State University, said the disease affects nearly eight in ten horses over age 15.

"It's the most common disorder affecting joints in horses, as well as in people, and one of the most common disorders that we treat overall in horses. It's one of the most common reasons horses present to a veterinarian," she said.

Pezzanite and her team are hoping to find markers of how osteoarthritis develops in horses by studying individual immune cells in joint fluid. Those markers may provide insights on how veterinarians can use gene therapies or other treatments at specific stages to slow the disease's progression.

Typically, people and animals only show signs of osteoarthritis at advanced stages, when they experience joint pain. Pezzanite believes information in immune cells might expose the disease much earlier, even before evidence appears on X-rays.

"Our goal with this work is to look at those very early stages in horses that have post-traumatic arthritis, so that we can determine that tipping point of when we should be intervening or not. And hopefully this will inform treatment in humans as well," she continued.

Pezzanite said people could benefit from this research if the immune markers can be translated across species. Physicians would have better information about when to intervene before full-blown osteoarthritis develops.

"If you're playing soccer and twist your knee, tear your ACL, we would potentially be able to take a sample of that joint fluid and know whether you're going to develop arthritis or not," she explained. "Which would allow us to be more aggressive in treatment of that joint."

Spring brings about migration season for birds, but home and workplace windows can often prevent them from getting to their final destination.

Wayne State University has been awarded a grant by The Detroit Zoological Society to conduct research on bird mortality from window strikes.

Ava Landraf, conservation and research coordinator with Detroit Bird Alliance, said more than half of the bird window strikes happen at low-rise and residential buildings, and not on skyscrapers as most would imagine.

"Most people don't know that bird-window collisions are the second highest cause of direct human-caused mortality of birds. And this is surpassed only by outdoor and feral cats," Landraf said.

The Smithsonian Institution finds many bird window strikes happen because of less darkness at night and an increase in artificial light caused by streetlights and lighted office buildings.

The research shows 33% of the world's population cannot see the Milky Way galaxy due to light pollution, and for birds that navigate using the stars, this hazy sky is having deadly results.

Landraf said Wayne State University faculty and students have had concerns about bird strikes over the years, but the opportunity to do something about it never materialized until they got this grant. She added it's scary to find a small number of dead birds around the campus, knowing there are many window strikes.

"A lot of the birds will hit a window, have that head trauma and then, fly off and then die later," Landraf said. "Even if they hit the window and they die right there, they're either picked up and eaten by a scavenger or the building caretakers just sweep the birds right up."

Based on the Detroit Bird Alliance's findings from tracking bird strikes, CollidEscape, an adhesive film that reduces reflections outside, was applied on the first- and second-floor windows of the university's Law School building as part of the research. She suggested people contact the Bird Alliance for other potential solutions, and also suggested checking the website birdmapper.org to see which areas experience more bird-window strikes around the world.


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