A bipartisan group of lawmakers has reintroduced the PASTEUR Act in Congress, which stands for Pioneering Antimicrobial Subscriptions to End Upsurging Resistance.
The legislation would encourage investment in the development of drugs to address what some have called "the antimicrobial resistance crisis." It also aims to improve the appropriate use and availability of antibiotics.
David Hyun, antibiotic resistance project director for The Pew Charitable Trusts, said antibiotic resistance is due to not having enough new antibiotics coming to the market in the last couple of decades. He added the antibiotic pipeline has been pretty dry, compared with where things were about three or four decades ago.
"This is a problem because our antibiotic arsenal has not been able to keep pace with the emergence of antibiotic resistance that we're seeing in patients," Hyun explained.
Hyun emphasized the PASTEUR Act is creating an economic incentive for the drug-development pipeline, to incentivize and make sure new antibiotics are being researched and developed and filling unmet needs and space of antibiotic resistance.
Cornelius Clancy, professor of medicine at the University of Pittsburgh, said a key component of the bill is to establish a subscription-style model for antibiotics. He pointed out the Department of Health and Human Services will pay for access to a given new drug which is active against antibiotic-resistant pathogens, and provide drugs to health care systems. Reimbursement to companies developing drugs will not be on a per-use basis for the use of the drug.
"So this model attempts to come up with a new way of reimbursing for antibiotics where people will purchase -- or systems will purchase -- access to the drugs," Clancy noted. "And then they can use them as often or as little as they like, and companies are not dependent upon dose-by-dose reimbursement."
Clancy stressed it takes 10 to 20 years to develop a new antibiotic for the pipeline. He added some new antibiotics introduced and reaching clinics over the past 20 years have almost without exception, failed economically. Therefore, companies have either left or chosen not to get into the antibiotic drug development space.
"And the reason that's important is we are seeing more and more resistant infections that we need new antibiotics for," Clancy cautioned. "That trend is only going to increase in the future."
Clancy added without some sort of effort to spur antibiotic development and to improve the economic prospects, for companies attempting to develop antibiotics then the U.S. runs into the risk in the future of not having enough antibiotics to fight infection-causing bacteria.
Support for this reporting was provided by The Pew Charitable Trusts.
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People who are part of the Deferred Action for Childhood Arrivals program, known as DACA, will be dropped from their CoveredCA health plans at the end of August.
The move comes after the Trump administration changed a Biden-era definition of "lawfully present" to revoke health care eligibility for thousands of immigrants.
Christine Smith, policy and legislative advocate for the nonprofit Health Access California, said people only have a few weeks to get medical appointments in before their coverage ends.
"If you're enrolled in Covered California and you're a DACA recipient, the Trump administration just ended your coverage," Smith emphasized. "People should use as much of your health care as you can before the August 31st deadline."
The Centers for Medicare and Medicaid Services defended the move, saying it will save taxpayers money. CoveredCA estimated the change affects about 2,400 DACA recipients in the state who make too much to qualify for Medi-Cal and have jobs not providing health insurance. They can still buy private insurance but it is much more expensive. People who prepaid for their coverage can seek a refund.
Smith predicted it will be a blow not just to those who lose coverage but to the state's health care system as a whole.
"The lines in the ERs are going to be longer because people are not going to be able to get affordable preventive care," Smith projected. "They're just going to get sicker and then end up in the ERs. People will overall incur more medical debt. Hospitals will have more uncompensated care."
The change is nationwide. As of mid-July, about 538,000 people in the DACA program across the U.S. are ineligible to enroll in any state-based insurance marketplace and are unable to access premium subsidies or cost-sharing assistance.
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Artificial intelligence is appearing more prominently in many aspects of life and research suggests older populations are curious, yet remain wary of using the technology in their everyday lives.
According to Stats Indiana, there are more than 1.5 million Hoosiers aged 65 and older, or 18% of the state's population. Experts said it is likely the demographic will use AI in some form in the next few years, either by choice or necessity.
Dr. Shaun Grannis, vice president of data and analytics for the Regenstrief Institute on Aging, said AI offers real benefits.
"It can reduce loneliness through conversation, provide reminders for medications and appointments," Grannis outlined. "It can support cognitive stimulation via games, storytelling, news updates."
The technology can also offer a low-pressure way to access information on public services, he added, which is valuable for those with mobility issues or those who feel intimidated by technology.
Grannis cautioned any tool which can be used for good can also lead to problems. He noted AI can create a false sense of companionship and mask social isolation. Overdependence is a legitimate concern, he argued, if the technology becomes a "crutch" for all forms of interaction.
"All cognitive activities or decision-making, it can actually lead to and create a negative feedback loop, lead to a decline in engagement and even basic self-management skills," Grannis explained. "This is risky."
Grannis believes one solution is designing AI systems to complement, not replace, human interaction. He stressed it can be done though building broader support ecosystems including family, friends, caregivers and community services. Grannis emphasized it would encourage real-world activity, prompting the user to go for a walk, call a grandchild or attend a local senior event.
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If you have an extra five minutes, you can save a life because you can learn cardiopulmonary resuscitation at no cost from a new mobile, hands-only CPR kiosk.
The new kiosk is in the lobby of Saint John's Health Center in Santa Monica. The machine's touch screen gives a brief overview of hands-only CPR and you can practice right there, on a mannequin.
Dr. Rigved Tadwalkar, cardiologist at St. John's, said it is an easy way for people to get more comfortable giving chest compressions in an emergency.
"It's a lot like a video game but of course, a lot more important than a video game," Tadwalkar pointed out. "It gives real-time feedback about the depth and rate of compressions, proper hand placement, which are all factors that influence the effectiveness of CPR."
The American Heart Association operates the St. John's mobile kiosk and a stationary model at L-A-X with support from the hospital. Santiago Canyon College in Orange County also has a mobile hands-only C-P-R kiosk now through September, sponsored by Edwards Lifesciences.
Steven Munatones, an Orange County business owner, said he survived what's known as a "widowmaker" heart attack which led to cardiac arrest nine years ago, thanks to his 17-year-old son, who gave him immediate CPR with instructions from a 911 operator.
"You don't have to put your mouth to anybody's mouth," Munatones explained. "You just put your hand on their chest and pump. He saved me, and others can do the same, anywhere. So, it's absolutely a lifesaving, heroic act that anybody can do."
Statistics show 350,000 Americans suffer from cardiac arrest outside a hospital each year and about 90% die, in part because they do not receive CPR. About 70% of those cardiac arrests happen at home, so people often depend on family or friends to give CPR before an ambulance arrives.
Disclosure: The American Heart Association Western States Region contributes to our fund for reporting on Health Issues. If you would like to help support news in the public interest,
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