A groundbreaking report from a team of Wayne State University researchers revealed fathers pass down more than genetics to their children. They are also sharing toxins.
The study found when adult male mice are exposed to a mix of old and new PFAS chemicals, it alters their sperm and affects the genes in their offspring's liver and fat. The substances have been widely used since the 1940s in consumer projects and industry.
Dr. Michael Petriello, toxicologist and assistant professor of environmental health sciences and pharmacology at Wayne State, worked on the study and said the results have been surprising.
"It was a such an interesting collaboration that I didn't know what to expect, because I had never done anything looking at paternal exposures," Petriello observed. "Every time that we expose these male mice, we see something - whether it's in the male themselves, or their offspring."
Studies show PFAS exposure also causes less testosterone in male rats and more estradiol, a female sex hormone. PFAS are a large group of synthetic chemicals resistant to oil, water and heat, giving them the nickname "forever chemicals."
Dr. Richard Pilsner, OB/GYN and professor of human growth and development at Wayne State, who co-authored the report, said while women often focus on their health before trying to become pregnant, planning is important for men too, and the three months before conception are most critical.
"During that period, it's very good to try and avoid environmental exposures and reduce your exposure to different factors that may negatively influence those sperm epigenetic patterns," Pilsner recommended.
DruAnne Maxwell, a doctoral student at Wayne State and co-author of the report, said she is grateful to Professors Pilsner and Petriello for what she called a revolutionary opportunity.
"PFAS, there's not a lot known about it, especially when it comes to reproductive science," Maxwell pointed out. "There's not a lot of emphasis on male contribution, and so we're trying to, like, turn the tides and show people that men do matter."
The team said more research is needed to understand how PFAS exposure before conception affects future generations.
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A majority of South Dakotans have voted to maintain a strict abortion ban but other factors are shifting the landscape for reproductive care in the state.
Of the 10 states voting on abortion during the 2024 election, South Dakota was one of three to keep a ban in place.
Kim Floren, director of the Justice through Empowerment Network, which provides financial assistance to people seeking abortions, said the state's view on the issue is not new but concern is growing over how the federal government may affect reproductive rights.
"I'm feeling the panic from people who are in areas that maybe haven't experienced what we've experienced as far as barriers go," Floren noted. "The reality is that we as a community can figure out how to take care of one another."
The Justice through Empowerment Network provides assistance with travel and transportation, child care, lodging, interpreters, birth control and medical procedure funding. Floren pointed out the organization supports 30 to 40 people per month. The final tally for Amendment G, which would have established a right to abortion in the state's constitution, was 41% for and 59% against.
South Dakotans voted in 2006 and 2008 against near-total abortion bans but Floren stressed since then, President-elect Donald Trump's first term made people feel "emboldened to be more vocal." Still, she acknowledged his second term will begin in a different context than his first.
"Before Dobbs, we did not have all of these reliable, safe websites where you can order abortion pills from and have them sent to your house for extremely cheap," Floren observed. "In some ways, access here has gotten better."
Floren added Gov. Tim Walz of Minnesota will return to his post after running for vice president on the Democratic ticket. Walz in 2023 signed a bill protecting patients who travel to Minnesota for abortion care and their providers from legal penalties in other states.
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It is now up to Wisconsin Supreme Court justices to decide the fate of an abortion law from the mid-1800s.
A circuit court determined last year an 1849 law does not apply to "medically consented" abortions in Wisconsin. The high court heard arguments Monday about whether a 1985 state law overrides the older one, allowing abortions before the point at which a fetus could survive outside the womb.
Jenny Higgins, professor of obstetrics and gynecology at the University of Wisconsin-Madison, said while the impact of this case is critically important, even if the 1849 law is determined to be unenforceable, returning to the status quo would mean a dire landscape for abortion access.
"Even though abortion is technically available at clinics in Wisconsin right now, it's heavily restricted," Higgins explained. "Because of insurance and Medicaid prohibitions, people have to pay out-of-pocket for a service that should be covered by insurance."
The 1849 law, which was brought to light after Roe v. Wade was overturned by the U.S. Supreme Court, prompted a statewide freeze on abortion services for more than a year. Higgins noted if Wisconsin's high court rules the law still applies today, the state would be looking at another abortion freeze.
Abortion access disproportionately affects those who are already the most marginalized, Higgins pointed out. She noted while people from all walks of life may find themselves needing abortion care, factors like poverty and racism make it much harder for some to achieve reproductive autonomy, compared to those with more economic and social resources.
"Those effects make it much harder for folks to be able to access contraceptive care, be in relationships that are stable and healthy and communicative, to be able to see past the end of the day into one's future if you are, again, mostly focused on your own economic scarcity or figuring out how to feed your kids, or figuring out how not to get evicted," Higgins outlined.
The 1976 Hyde Amendment, established three years after Roe v. Wade, prohibits the use of federal funds for abortion. Higgins hopes federal lawmakers will focus more on this amendment when considering the barriers to abortion care.
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Strong reactions are pouring in from both sides as Missouri voters made history by adding abortion rights to the state constitution.
The decision to pass Amendment 3, the "Right to Reproductive Freedom Initiative," makes Missouri the first state to overturn a near-total statewide abortion ban. Advocates and opponents are now gearing up for future battles.
Jamie Morris, executive director and general counsel of the Missouri Catholic Conference in Jefferson City, said he is disappointed with the passage of the amendment but emphasized his organization's pride in the conference's efforts, despite limited resources, and vowed the fight is not over.
"From the church's perspective, win or lose, we were going to continue to advocate for policy to help address the needs of women to help them choose life to begin with," Morris explained. "So that not only you're dealing with, necessarily, the supply of abortion, but also the demand."
In addition to abortion rights, Amendment 3 protects access to contraception and reproductive health services.
Meanwhile, pro-choice advocates in Missouri including Planned Parenthood and the ACLU are celebrating the passage of the amendment, while filing a lawsuit to block some restrictions, including parental consent for minors and continued regulatory oversight of abortion services.
Maggie Olivia, senior policy manager for the advocacy group Abortion Action Missouri, applauded the vote.
"I could not be more proud of the first steps that we are taking together as Missourians to dismantle the decades of political infringements on our access to abortion and, frankly, all reproductive care," Olivia stressed.
Missouri was among nine states with abortion rights measures on the 2024 general election ballot. Amendment 3 takes effect Dec. 5.
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