By Seth Millstein for Sentient.
Broadcast version by Kathleen Shannon for Texas News Service reporting for the Sentient-Public News Service Collaboration
Bird flu has been making a comeback, with multiple strains detected in multiple people across multiple continents over the last few months. As of this writing, three people in the U.S. have contracted the H5N1 strain, one person in Mexico has died from the H5N2 strain, and H5N1 has been detected in 118 U.S. dairy herds across 12 states. Thankfully, the disease is not easily transmissible between humans - but some epidemiologists fear that eventually, it will be.
Here's what you need to know about bird flu and human health.
What Is Bird Flu?
Bird flu, also known as avian influenza, is shorthand for influenza type A viruses and the illness they cause. Although avian influenza is common in birds, non-avian species can contract it as well.
There are many, many different strains of bird flu. However, most strains are what's called low pathogenic, meaning they're either asymptomatic or only cause mild symptoms in birds. For instance, low pathogenic strains of avian influenza, or LPAI, might cause a chicken to have ruffled feathers, or produce fewer eggs than normal. But high pathogenic strains of avian influenza, or HPAI, cause severe and often deadly symptoms in birds.
It's important to note, though, that this distinction between LPAI and HPAI strains only applies when avian species contract it. A cow who gets an LPAI strain of bird flu might experience severe symptoms, for instance, while a horse who gets an HPAI strain might be asymptomatic. In humans, both LPAI and HPAI strains of bird flu can cause both mild and severe symptoms.
Can Humans Get Bird Flu?
We sure can.
Bird flu strains are categorized on two different spectrums based on two different proteins on their surface. The protein hemagglutinin (HA) has 18 different subtypes, labeled H1-H18, while the protein neuraminidase has 11 subtypes, labeled N1-11. The two proteins combine with one another to create unique strains of bird flu, which is why strains have names like H1N1, H5N2, and so on.
Most of these strains don't affect humans, but a handful of them do. Several strains have been particularly concerning to epidemiologists:
The current strain of bird flu that's been detected in humans is H5N1.
How Do Humans Get Bird Flu?
In very rare cases, it's possible for
bird flu to pass from human to human. Most of the time, though, humans get bird flu by coming into contact with infected animals or their byproducts. This could mean touching the carcass, saliva or feces of an infected bird; however,
bird flu is also transmissible by air, so merely breathing while in the vicinity of an animal with the virus can also be enough to contract it.
There are no documented cases of humans
contracting bird flu by drinking raw milk, but some recent cases suggest that it may be a possibility. The current strain has been detected in cow's milk, and in March,
several cats died after drinking raw milk from a cow who'd been infected with the virus.
What Are the Symptoms of Bird Flu?
At the risk of stating the obvious,
the symptoms of bird flu in humans are generally what one would describe as "flu-like," including:
- Fever
- Sore throat
- Runny or stuffy nose
- Nausea and vomiting
- Coughing
- Fatigue
- Muscle aches
- Diarrhea
- Shortness of breath
- Pink eye
Birds who've contracted avian flu, on the other hand, might display slightly different symptoms, including:
- Decreased appetite
- Purple discoloration of body parts
- Lethargy
- Reduced egg production
- Soft-shelled or misshapen eggs
- General respiratory issues, such as nasal discharge, coughing and sneezing
- Lack of coordination
- Sudden, inexplicable death
Can Humans Die of Bird Flu?
Yes. In the three decades since bird flu was first detected, 860 humans have contracted it, and 463 of them died. This means the virus has a staggering
52 percent mortality rate, though there have been no deaths in the U.S. attributed to the most recent spread of the disease here.
Who Is Most At Risk of Contracting Bird Flu?
Because the disease is primarily transmitted to humans through animals and their byproducts, people who spend time around animals are at the highest risk of contracting bird flu. Wild and farmed animals pose the greatest risk, but even dogs can get bird flu if, for instance, they come across the infected carcass of an animal who had it. Domestic pet owners
whose animals don't go outside are not at risk.
Occupationally-speaking, the people most susceptible to getting bird flu are
those who work in the poultry industry, as they spend a significant amount of time around birds, their byproducts and their carcasses. But livestock workers of all sorts are at a high risk; the first person to test positive for this most recent strain works in the dairy industry, and is
believed to have caught it from a cow.
Other people who face elevated risks of bird flu include hunters, butchers, certain conservationists, and anybody else whose line of work involves touching potentially infected animals or their carcasses.
What's Going on With the Current Strains of Bird Flu?
The H5N1 strain has been
slowly spreading across the globe since 2020, but it wasn't until March that it was
detected in the unpasteurized milk of U.S. dairy cows. This was significant for two reasons: it was the first known instance of that strain infecting cows, and it was discovered in multiple states. By April, it had spread to
13 herds across six different states.
Also around that time,
humans began contracting H5N1. The first two people only experienced mild symptoms - pinkeye, to be specific - and quickly recovered, but the third patient
experienced coughing and watery eyes as well.
That may sound like a minor distinction, but because a virus is much more likely to be spread through coughing than an eye infection, that
third case has virologists on edge. All three were farmworkers who'd had contact with dairy cows.
By May, H5N1 had been detected in the muscle tissue of a dairy cow - though the meat didn't enter the supply chain and had already been marked as tainted, as the cow was sick beforehand - and by June,
cows infected with the virus had died in five states.
Meanwhile, a man in Mexico
died after contracting H5N2, a different strain of bird flu that had never before been detected in humans. It's unclear how he contracted it.
To be sure, there's no reason to believe that a widespread outbreak among humans is imminent, or even possible (yet). But the fact that there have been so many bird flu "firsts" in such a short time has many experts concerned, as it raises the possibility that a strain could mutate and become more easily transmissible to humans.
While much of the coverage of H5N1 has focused on cows, the current outbreak has wrought havoc on chickens, too: As of June 20, more than
97 million poultry have been affected by H5N1, according to the CDC.
Is Drinking Raw Milk An Effective Deterrent Against Bird Flu?
Absolutely not. If anything, coming into contact with
raw milk increases your exposure to bird flu, not to mention your risk of contracting
other potentially serious illnesses.
In April, the Food and Drug Administration announced that
1 in 5 milk samples from grocery stores were found to contain traces of H5N1. That's not quite as alarming as it sounds; these milk samples were pasteurized, and
preliminary studies show that pasteurization neutralizes, or "inactivates," influenza type A viruses.
What's especially worrisome is
sales of raw milk have been increasing since the latest bird flu outbreak, spurred in part by viral
misinformation spread by health influencers touting raw milk.
Could Bird Flu Become a Human Pandemic?
Though it's difficult to say for certain, the general consensus in the scientific community is that the extant strains of bird flu are, in their current forms, unlikely to reach pandemic levels. The reason for this is that they almost never pass from one human to another, and are instead contracted from animals.
But viruses mutate and change over time, and
the long-gestating fear among epidemiologists is that a strain of bird flu will mutate, or undergo a genetic reassortment, in such a way that allows it to be easily transmitted from human to human. If this were to happen, it could very plausibly
become a global pandemic for humans.
How Is Bird Flu Diagnosed?
In humans, bird flu is detected via a simple throat or nasal swab, but infectious disease experts warn that much like the early days of the Covid pandemic,
we aren't testing most of the population or measuring disease spread in wastewater. In other words, we don't know for sure whether the disease is circulating. Physicians don't routinely test for bird flu, so you'll have to specifically request a test if you're concerned that you might have it.
Do Standard Flu Shots Protect Against Bird Flu?
No. The
current annual flu shot that we're all encouraged to get protects against the common flu, including swine flu,
but not avian influenza.
The Bottom Line
Development is underway for a new bird flu vaccine, and the CDC says that despite all of these recent developments,
the public health risk of bird flu is still low. But there's no assurance that this will always be the case; as a highly fatal virus with multiple, mutating strains, bird flu is a constant looming threat for humans and animals alike.
Seth Millstein wrote this article for Sentient.
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By Nina B. Elkadi for Sentient.
Broadcast version by Mark Moran for Iowa News Service reporting for the Sentient-Public News Service Collaboration
In Iowa, a state with a population of around 3.2 million, around 6,000 people will die from cancer in a given year.
Each year, the Iowa Cancer Registry is tasked with reporting on the status of the disease within the state. In 2024, their report made national headlines because of Iowa’s outlier status as the state with the fastest growing cancer incidence and the second highest incidence rate behind Kentucky. The state registry chose to focus its report on the carcinogenic effects of alcohol and high rates of binge drinking in the state, with no mention of the millions of gallons of factory farm manure pumped into Iowa waterways each year.
In its 2024 “strategies to significantly reduce the burden of cancer in Iowa” section, the Iowa Cancer Registry did not mention agricultural pollution once.
In Iowa, animals in factory farms (around 55 million chickens, 53.4 million hogs, 11.5 million turkeys, and 3.7 million cattle and cows) produce around 109 billion pounds of manure. Some of that manure is sprayed on crops as fertilizer. Some of it is illegally discharged from manure lagoons into public waterways. Pesticides and other chemicals are also sprayed on crops and can leach into groundwater. These non-behavioral exposures to carcinogens are causing some experts — including those criticized for not doing enough — to call for further research into the intense industry that uses the vast majority of land in the state.
The issue with cancer, like many other diseases, is that causation is difficult to tie to one source, says Peter Thorne, professor of Occupational and Environmental Health at the University of Iowa College of Public Health. If someone was diagnosed with bladder cancer who lived in an area with high levels of arsenic (a known human carcinogen) in their drinking water, but that person was also exposed to chemicals in their water, and pesticides, and might also eat grilled meat, exactly what caused the bladder cancer is difficult to prove. Another carcinogenic exposure pathway in Iowa is radon, a colorless, odorless radioactive gas that is present in Iowa due to prior glacial activity.
“In a case like that, you can’t say this person’s bladder cancer derived from that one exposure,” Thorne tells Sentient. “You don’t have sufficient data on that person’s lifetime exposure to say that, and even if you did, you can’t be sure that in their case, [one thing] caused it.”
The Nitrate Problem
Despite the difficulty to determine causation for most cancers, one carcinogenic substance is the devil lurking beneath the surface in agricultural states like Iowa. Nitrate is an agricultural byproduct: Ammonia in natural and synthetic fertilizer is converted by soil bacteria into highly water-soluble nitrate through a process called nitrification. If over-applied, nitrate leaks into aquifers and can contaminate water systems.
Throughout the last two decades, the link between nitrate exposure and cancer has become more well-defined. According to Brandi Janssen, clinical associate professor in the Department of Occupational and Environmental Health at the University of Iowa College of Public Health, the colorectal cancer linkages to nitrate are “fairly substantial.” Colorectal cancer is the one of most common cancers in Iowa, the Registry reports.
In internal emails reviewed by Sentient, in an email to Senator Charles Grassley ahead of a meeting with his office in D.C., Iowa Cancer Registry director and principal investigator Mary Charlton describes the “knee jerk” reactions people have to the potential carcinogenic risks of agricultural contamination:
“As you can imagine, it has been a tricky road to alert Iowans about our high cancer risks and try to focus on mitigating the known risks for cancer, while navigating the barrage of knee jerk reactions many people have about it being due to chemicals in the water or the pesticides, nitrates, etc,” Charlton wrote in an email on May 13, 2024.
In a request for comment, Charlton clarified to Sentient that she was not dismissing potential agricultural exposures. “Any time we promote established public health messages about any lifestyle factors that have been demonstrated to contribute to cancer, we are perceived by some as trying to evade the role of agricultural exposures.”
She continued: “People are certainly right to be concerned, and we feel strongly that more research needs to be done to better quantify the contribution of agricultural exposures to our cancer incidence while taking into account the other known risk factors at the individual level such as tobacco use, physical inactivity, poor diet, alcohol consumption, ultraviolet light exposure, and infectious agents, to name a few.”
Based on all of the questions her office has received about environmental exposures, Charlton wrote to Sentient that she asked the University of Iowa Environmental Health Sciences Research Center to consider making fact sheets on nitrate and other environmental risk exposures in Iowa, which they have done.
The nitrate fact sheet states that exposure to nitrate is a probable human cancer risk. A 2020 systematic review of the literature on nitrate contamination and water found that, “there is an association between the intake of nitrate from drinking water and a type of cancer in humans.”
The current legal limit of nitrate in public drinking water is 10 mg/L, a standard set to protect infants from methemoglobinemia, also known as blue-baby syndrome. Keeve Nachman, Professor of Environmental Health and Engineering at Johns Hopkins and Associate Director of the Center for a Livable Future, tells Sentient that a lot has changed in nitrate research since the Environmental Protection Agency first established those limits.
“As with many chemicals, it’s important to go through the process of systematically evaluating the evidence and drawing conclusions from a formal analysis. I also think it’s really important that we don’t wait,” he says.
A recent report by the non-profit advocacy group Food & Water Watch details the extent of nitrate pollution in Iowa and the effect this pollution has on the health outcomes of its residents. As Sentient has previously reported, Iowa is a state where illegal manure discharges are the norm, and attempts to increase regulation enforcement have fallen short. These discharges are impairing waterways and contributing to what some are calling a water quality crisis.
On February 27, President Donald Trump announced that the Environmental Protection Agency would be cutting spending by 65 percent. Mary Grant, Water Program Director at Food & Water Watch wrote in a statement that, “Such a cut would have a devastating impact on the critical clean water and environmental programs that communities rely on each year to fix broken drinking water systems, stop sewage spills and clean up toxic sites.”
Nitrate contamination, Thorne says, “is one of the major exposures that people point to as perhaps contributing to the high rate of cancer that we see in Iowa.”
Other Agricultural Risks
Other agricultural contaminants are contributing to Iowa’s worsening water, and health, crisis. Pesticides, which encompass herbicides and other chemicals, are another likely culprit.
The term “pesticides” encompasses a barrage of chemicals, Janssen explains.
“We like stories that are straightforward. One thing causes another, and unfortunately, that’s just not the way it works in cancer. It’s not the way it works in environmental health. We have multiple exposures that can cause multiple different types of health outcomes,” she says. “When people comment on, say, pesticides causing cancer in a particular setting, it’s like, well, what kind of pesticide and what kind of cancer are you talking about?”
For Elise Pohl, a researcher on concentrated animal feeding operations and a community health consultant at the Iowa Department of Health and Human Services, thinking about exposure in a place with a lot of environmental toxins complicates the picture.
“It just kind of makes you think about the environment and ecosystem that you live in and what you’re exposed to,” she says. “Not just the behaviors that you have, or the risk factors that one may have personally, whether they’re obese or they drink alcohol or smoke cigarettes, but also this external environment whether it’s in their homes or outside their homes.”
A new law advancing in the Iowa legislature would ban cancer victims’ ability to sue pesticide manufacturers; the law was written by Bayer (which acquired Monsanto in 2018).
The Future of the State
In January, Iowa Governor Kim Reynolds, whose husband is currently in remission for lung cancer, vowed to allocate $1 million toward cancer research.
“Every case of cancer is a tragedy. And I’m concerned by the data showing that these tragedies disproportionately affect Iowans. Our state has ranked second for new cancer cases two years running, and we’re one of just two states with rising rates,” she said in her 2025 Condition of the State address. “That’s the ‘what’ of this problem; the ‘why’ and the ‘how’ are where things get tricky. According to the Iowa Cancer Registry, we’re in the top-five states for binge-drinking.”
In an email to Sentient, Charlton wrote that the Iowa Cancer Registry “will be partnering with investigators at the National Cancer Institute who direct the Agricultural Health Study – which involves over 50,000 pesticide applicators in Iowa — to get their assistance in summarizing their findings on agricultural exposures and cancer in a future report.”
Additionally, Charlton wrote that she has been working with the University of Iowa Holden Comprehensive Cancer Center to create a panel of epidemiology experts from across the country, “including people with expertise in environmental risk factors, to get their recommendations on studies and analyses that should be undertaken to better understand the driving factors behind our high cancer rates in Iowa.”
Looming above all of this is the constantly changing federal funding landscape, which could impact cancer research. Richard Deming, medical director of the MercyOne Richard Deming Cancer Center in Des Moines, Iowa said at a press conference in Iowa City that he has already seen the cuts impact work in the state.
“We have over 60 clinical trials that are open at our cancer center for enrolling patients. Just two weeks ago, one of them was closed. It happened to be a clinical trial that was looking at special needs of the LGBTQ community, and we were just told it’s closed,” he said. “Just two weeks ago, one of our workers who had been with us for about a year and a half received a pink slip because she was still under the probationary period.”
Mark Burkard, professor of internal medicine in the University of Iowa Carver College of Medicine and Director of Holden Comprehensive Cancer Center, is especially worried about how universities will “train the next generation” without continued funding or philanthropy to fill in the gaps.
“Those graduate students who would have been conducting the research now and over the next few years would be the research leaders who are investing in that career 10 years from now. So I’m very concerned about how this is going to play out,” he said.
The 2025 Iowa Cancer Registry report, released on February 25, focused on cancer survivorship.
“It’s a great day to be alive,” Deming said at the press conference. He announced that there will be about 171,000 cancer survivors in Iowa this year — the mortality rate is decreasing as quality of care increases, he said.
“Forty-five percent of cancers in the United States are caused by modified risk factors, things that we have control over,” Deming said. “The type of food we eat, physical activity, alcohol consumption, whether or not you get an HPV vaccination, radon, environmental chemicals, all of these things contribute to the 45 percent of all cancers that are caused by modifiable risk factors.”
At the press conference in Iowa City, Deming also said that more research needs to be done on “Iowa’s especially high incidence of cancer,” by looking at environmental factors like radon and chemicals.
One “philosophical issue” Deming is especially interested in is helping cancer survivors with is their mental wellbeing:
“How do you find joy in life knowing that it’s going to end from cancer?”
Nina B. Elkadi wrote this article for Sentient.
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