Researchers at Iowa State University are taking the next step in genetic medicine by targeting diseases in a person's RNA.

Most drugs target proteins to interrupt the disease process.

Iowa State University Assistant Professor of Biochemistry Walter Moss said they've moved beyond targeting proteins, and are taking aim at disease on a smaller level - focusing on ribonucleaic acid, or RNA.

This will allow scientists to create 'personalized disease attackers' that Moss said fit perfectly into 'pockets' in a patient's cells.

"So, there's the different pockets on a protein drug target," said Moss. "You'd be able to get that drug into that pocket, either to interfere with the protein function or the protein interaction in some way. And the same idea would be with RNA."

Moss said the RNA approach could be used to target cancer and genetic diseases, but adds years of testing remain before the technology will be ready for the commercial market.

Moss said 90% of the body's genome is turned into RNA as opposed to just 10% that becomes protein. He explained that dramatic ratio presents scientists with new opportunities.

"It opens up whole new avenues of targeting diseases that aren't currently possible at the protein level," said Moss. "Because now you can start to treat RNA-related diseases, or diseases where there is no good protein drug target."

Moss said COVID vaccines harnessed the power of what's known as "messenger RNA," which caused a spike in interest in using RNA science more broadly to treat other diseases.




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In 2020, the Cameron Peak Fire burned more than 200,000 acres, destroyed 469 structures and forced the evacuation of more than 6,000 residents in Colorado.

Since then, researchers have documented how the scars of wildfires influence adaptation, build resilience and offer insight into how communities can better prepare for and recover from natural disasters.

Pilar Morales-Giner, a postdoctoral researcher at the University of Granada in Spain, said as wildfires scorch forests or communities, they also affect our connection to the places.

"In addition to this tragedy of losing a home, when a fire burns an emblematic community building, for example, or a trail or a forest that we usually go to, this also affects what connects people to places," Morales-Giner explained.

Colorado State University researchers interviewed 34 Larimer County residents, local leaders and environmental organizations to learn how the largest wildfire in Colorado history affected them. The results, "Ash Everywhere: Place Attachment and Meanings in the Aftermath of Wildfires," were recently published in Sage Journal.

Anne Mook, senior team scientist for the Institute for Research in the Social Sciences at Colorado State University, said wildfires are incredibly disruptive for people's lives and stressful to people's mental health. But she added people are also drawn closer together after natural disasters to rebuild homes, schools and churches, which strengthens social bonds and resilience.

"There's also this message of hope that these kinds of events can be a catalyst for growth and unity and building new and stronger connections with our environment," Mook observed.

Researchers also found communities affected by wildfire are more open to different mitigation strategies, including prescribed burns, which improve soil health and help trees grow faster.

"These things that initially were very much met with resistance now are much more embraced and people are learning," Mook noted. "These are practices that have been used for a very long time, for example, in the U.S. South, but also by the Native Americans."

This story is based on original reporting by Stacy Nick for The Audit.

A new State of the Commonwealth report by Old Dominion University finds Virginia had a strong year in 2024. But researchers say challenges remain.

The report finds housing will be a major issue in the state, as local governments work to address housing shortages and zoning laws.

Virginia had its fourth straight year of economic growth in 2024, ranking as the number one state to do business.

Bob McNab, professor of economics at Old Dominion University, said the overall outlook for Virginia in 2025 is positive. But he said a number of factors may impact that forecast.

"We saw inflation decelerate, real wages - that's wages after inflation - rise, jobs continue to increase," said McNab. "As Virginia enters 2025, it is in a good position to continue growth."

McNab did warn that international trade, immigration, and the status of the federal workforce could impact Virginia's economy.

Despite data that points to a strong economy, consumers aren't quick to agree.

The report finds consumers still feel less optimistic about the state of the economy than before the COVID-19 pandemic.

Higher prices on goods and services because of inflation have driven that sentiment. McNab said people interact with prices daily - and their paycheck may be once or twice a month.

That, he said, leads to the data not coinciding with consumer feelings on the economy.

"And since 2019, real hourly earnings have increased after accounting for inflation," said McNab. "People's wages have outgained inflation. But they don't feel like that has occurred because they see prices much more frequently."

The report also finds Virginia's unemployment rate is nearing record lows.




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As the popular role-playing game Dungeons and Dragons turns 50, one Colorado State University instructor suggests today's political leaders could learn a lot by rolling the dice.

James Fielder, instructor and researcher of ludology (the study of games and gameplay) at Colorado State University, calls the game a master class in political strategy, covering everything from diplomacy to alliance forming to conflict resolution.

Fielder said players have to work together to achieve a goal. If you're at odds with each other, you don't achieve anything.

"The lesson is that we're learning to negotiate in order to overcome a challenge," Fielder explained. "That lesson sticks. You come out of the table, 'Oh, I learned how to negotiate with other people, and we overcame a challenge.' It worked."

A former Air Force lieutenant colonel, Fielder has more than two decades of experience designing war games and training exercises. He stressed role-playing is not just child's play. He compared the games to a ritual performance. When players are inside a game space -- which could be a football field, a card table, or a war room -- everything inside the game is very real, including wins, losses and lessons learned about the use of power.

Fielder added when a Dungeon Master reveals an unintended consequence of the players' decisions -- for example, the massacre of an entire town -- they frequently look at each other like, "What did we just do?"

"You will also find players who will play evil characters, who carry out atrocities in the game," Fielder observed. "But then when they come out, they don't feel good about themselves. They feel unclean, like, 'Oh my God, I can't believe I just did that.' And so, yes, that sends a very powerful message."

Fielder said even in today's modern age, games can be similar to an animist rite of passage, where participants believe a spiritual leader wearing an animal's skin is an actual god or animal.

"If you're wearing a suit to go to work, you're wearing the 'skin' of a businessperson," Fielder pointed out. "I was in the military for 25 years putting on the uniform, and wearing the 'skin' of a sergeant or a lieutenant colonel."

This story is based on original reporting by Stacy Nick for Colorado State University.